In patients with cellulitis or soft tissue infection, assess the severity of the infection and complicating comorbidities to determine the need for oral or parenteral antimicrobials.
Treat patients with mild, uncomplicated cellulitis who are not at high risk for MRSA with oral antibiotics that have activity against both staphylococci and streptococci; using cephalexin or dicloxacillin as first-line agents in most non-penicillin allergic patients.
Treat patients with mild, uncomplicated cellulitis who are at risk for MRSA infection with oral antimicrobials that have activity against MRSA and streptococci such as clindamycin, trimethoprim-sulfamethoxazole, and others.
Treat patients with MSSA soft tissue infections that are moderate to severe with a semisynthetic penicillin, a cephalosporin, or one of a number of other options.
Treat patients with moderate to severe cellulitis with systemic manifestations of infection who are at risk for MRSA with antimicrobial agents that have activity against MRSA and streptococcal infections.
Administer prompt antimicrobial therapy and thorough surgical debridement to patients who have evidence of gangrene.
Treat infections due to human and animal bites with appropriate antibiotics, starting with amoxicillin/clavulanate in outpatients receiving oral therapy.