Musculoskeletal pain with tenderness at specific locations is the hallmark of FMS.
Apply the American College of Rheumatology criteria in diagnosing FMS.
Patients may have other symptoms such as fatigue, difficulty sleeping, and feeling of swelling, as well as symptoms associated with disorders that are associated with FMS.
Ask about aggravating factors and triggering factors.
There is no objective swelling on exam and no laboratory abnormalities.
Take a careful history of psychiatric symptoms and assess the patient's psychological/psychiatric status, as psychological distress occurs in 20% to 40% of patients with FMS and may trigger or perpetuate symptoms.
Use clinical evaluation and selected laboratory studies to separate FMS from other diseases with similar presentation.
Consider screening patients with RA, SLE, and PSS for concomitant FMS as the occurrence of FMS in the patients is much higher than expected in a general population.