Treat outpatients with no cardiopulmonary disease and no modifying factors with a macrolide (azithromycin or clarithromycin) or doxycycline.
Treat outpatients with cardiopulmonary disease and/or modifying factors with either an antipneumococcal quinolone (levofloxacin or moxifloxacin) or a β-lactam (cefuroxime, cefpodoxime, amoxicillin/clavulanate) with a macrolide.
Treat inpatients with no cardiopulmonary disease and no modifying factors with an intravenous macrolide (azithromycin) alone.
Treat inpatients with cardiopulmonary disease and/or modifying factors with an intravenous antipneumococcal quinolone or an intravenous β-lactam with a macrolide.
Treat ICU patients with no risk factors for P. aeruginosa with an intravenous β-lactam plus either a macrolide or a quinolone.
Treat ICU patients with risk factors for P. aeruginosa with an intravenous antipseudomonal β-lactam (cefepime, piperacillin/tazobactam, imipenem, meropenem) plus an intravenous antipseudomonal quinolone (ciprofloxacin) or an intravenous antipseudomonal β-lactam with an aminoglycoside plus either an intravenous macrolide or an intravenous antipneumococcal quinolone.
Treat ICU patients with the addition of linezolid or clindamycin in combination with vancomycin if community-acquired MRSA is suspected.