Treat outpatients with no cardiopulmonary disease and no modifying factors with a macrolide (azithromycin or clarithromycin) or doxycycline.
Treat outpatients with cardiopulmonary disease or modifying factors, or both, with either an antipneumococcal quinolone (levofloxacin or moxifloxacin) or a β-lactam (cefuroxime, cefpodoxime, amoxicillin/clavulanate) with a macrolide.
Treat inpatients with no cardiopulmonary disease and no modifying factors with an intravenous macrolide (azithromycin) alone.
Treat inpatients with cardiopulmonary disease or modifying factors, or both, with an intravenous antipneumococcal quinolone or an intravenous β-lactam with a macrolide.
Treat ICU patients with no risk factors for P. aeruginosa with an intravenous β-lactam plus either a macrolide or a quinolone.
Treat ICU patients with risk factors for P. aeruginosa with an intravenous antipseudomonal β-lactam (cefepime, piperacillin/tazobactam, imipenem, meropenem) plus an intravenous antipseudomonal quinolone (ciprofloxacin) or an intravenous antipseudomonal β-lactam with an aminoglycoside plus either an intravenous macrolide or an intravenous antipneumococcal quinolone.
Treat ICU patients with the addition of linezolid or clindamycin in combination with vancomycin if community-acquired MRSA is suspected.